How can I stay sane with a wife I love when she is a messy person.For 18 yrs I heard every excuse.?

I have tried everything.So many times I've cleaned house and she gets angry saying I am throwing things that could be important or I an not sensitive to her things.So I thought to ask if I could have one room in the house.The choice was the office.This should be organize and where I can meditate.Well then comes the virus.Slowly spreading.We talk talk and finally it became a epicdemic.My last resort before departing is buy a 3 bdrm home and meld 2 rooms into one for me to sleep shower study.Another word make it a small studio for me including sleeping and not for her to used it for any reason.What do you all think about this?